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Microbiome & Microbial Ecology

How Our Gut Microbes Hold the Key to Fighting Inflammation

2025-06-10 · 2 min read

This is Part 4 of our series on the microbiome. This week, I'll be sharing about the relationship between our microbiome and inflammation.

New to the series? Catch up on: ➡️ Part 1, ➡️ Part 2, and Part 3.

When I tell people about my recent interest in the gut microbiome, they often look puzzled.

"Don't you fight bacteria?" they ask. "I thought you spent years studying how to kill them effectively?"

Both are true.

In summary, I have developed a healthy respect for microbes,

I respect them because I know how easily they can change the course of a life or devastate a family through illness or death from severe infection.

Now I have additional respect for them for a different reason: I see their potential to provide options that prevent death from illness and diseases, including infection.

Here's what I've observed in my years of studying the microscopic world:

These trillions of tiny neighbors living in our gut aren't just along for the ride.

They've been our partners in health, our protectors against disease, and the conductors of a complex dance that determines whether we stay well or get sick.

Inside our gut lives a bustling community of 100 trillion microbes.

They are actively communicating with our immune system every single day.

Some are sending messages that say "calm down, everything's okay," while others might be shouting "danger, fight back!"

This constant conversation determines your body's level of inflammation.

And inflammation, as we've learned, 𝐥𝐢𝐞𝐬 𝐚𝐭 𝐭𝐡𝐞 𝐫𝐨𝐨𝐭 𝐨𝐟 𝐬𝐨 𝐦𝐚𝐧𝐲 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬 𝐭𝐡𝐚𝐭 𝐚𝐟𝐟𝐞𝐜𝐭 𝐨𝐮𝐫 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐚𝐧𝐝 𝐥𝐨𝐯𝐞𝐝 𝐨𝐧𝐞𝐬

— from heart disease and diabetes to depression and even Alzheimer's.

The beautiful thing about studying ᴍᴇᴛᴀɢᴇɴᴏᴍɪᴄꜱ (essentially reading the genetic blueprint of all these microbes at once) is that we can finally see this conversation happen in real time.

We can observe not just who's there, but what they're actually doing.

Take inflammatory bowel disease.

For years, we've watched patients struggle with unpredictable flares, harsh medications, and the emotional toll of a body that seems to be fighting itself.

But when we understand that specific microbial communities can either fuel this inflammation or calm it down,

we open up entirely new possibilities for gentle, personalized healing.

Every person carries a unique microbial fingerprint, as individual as their personality.

Some people naturally harbor bacteria that keep inflammation in check.

Others, due to factors like genetics, diet, stress, or past antibiotic use, may have communities that tend toward inflammatory responses.

Studies have shown patients with chronic kidney disease whose gut microbes showed dramatic diversity loss compared to healthy individuals.

The research backs this up, that microbial disruption directly links to the inflammation and metabolic changes that worsen their condition.

But here's the wonderful news that gives me hope:

These microbes in communities can change.

They can heal. 🥰

.....to be continued

Next week in Part 5, we'll be diving deeper into The Gut-Inflammation Connection and what you need to know. Stay tuned!

What's your experience been with inflammation and gut health? Have you noticed connections in your own life or practice?

I'd love to hear your thoughts in the comments below.

And if this resonated with you, please share it with someone who might benefit from understanding this incredible relationship between our microbiome and our health.